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Bioprocessing Equipment
Outperform your competitors: specify bioprocessing equipment that delivers superior performance and efficiencies at laboratory, pilot and production level. Empower your innovation with faster, smarter, more accurate bioprocessing.
Why BPS Crowthorne? We partner with the world-class manufacturers to provide you with options that will meet your project requirements. Not as a ‘catalogue’ company, but as a trusted technical solutions provider with decades of experience. Adding value by advising and delivering what you need.
We research your requirements thoroughly before recommending options, so you can invest in holistic, strategy-based bioprocessing solutions that make a real difference from day one whilst continuing to add value as you scale up.
Take A Look Our Product Ranges Below
Avestin EmulsiFlex High Pressure Homogenisers
BPS Crowthorne is the exclusive distributor in Ireland for world-class Avestin EmulsiFlex high pressure homogenisers for research, pilot and scaled-up production. Applications include cell disruption/lysis, liposomes, nanoemulsions, particle size reduction and nanoparticles
Avestin systems are GMP-suitable with 21 CFR Part 11 compliance. These cutting-edge homogenisers:
- ensure particle size reduction within the nanometre range
- maximise reduction of polydispersity for optimum uniformity
- determine flow or batch times
- produce higher yields in less time
- offer near-perfect scale-up potential
- calculate and define final product quality.
Avestin high pressure homogeniser systems can process the toughest samples with pressures up to 30,000 psi, enough to ensure efficient lysis of E.coli (15,000-20,000 psi) and yeast strains (at least 25,000 psi).
A wide range of models provides a smooth transition from laboratory to production scale requirements. Solutions include systems for pharmaceutical companies, contract research organisations (CROs) and contract manufacturing organisations (CMOs).
Advanced Simplicity For Optimum Results And Maximum Reliability
At the heart of each machine is Avestin’s unique, self-regulating homogenising valve which maintains itself once the desired pressure is achieved.
This optimum solution outperforms traditional fixed/static valves which are vulnerable to blocking when presented with more difficult products. Avestin’s self-regulating valve opens to allow the blockage to pass through with little or no interruption – eliminating the need to remove a blocked valve and backflush it (which wastes time and product). Dynamic homogenising valves also minimise erosion.
If the EmulsiFlex’s homogenising valve does need to be inspected, it can be disassembled in just a few seconds. There are few moving parts and no O-rings in the product path. Virtually all contact parts are metal-to-metal or metal-to-ceramic. Avestin also builds its own pumps to a high specification to ensure maximum reliability, which are also easy to clean and service.
- Minimum sample size 10 mL; capacity up to 1,000 litres/hour; short product path ensures minimal hold-up volumes <1 mL
- Sterile applications, aseptic applications
- High controllable pressures
- Cleaning-in-place (CIP), sterilisation-in-place (SIP)
- Suitable for cGMP manufacture
- Reproducible results
- Scalability
- Quick and easy disassembly, minimal maintenance
- Fully autoclavable product path
- Reliable, leak-free design
- Continuous or batch operation.
Accessories include Automatic Homogenising Pressure Control – enabling users to input the desired pressure to a touchscreen HMI for greater accuracy and consistency (and mirroring GMP-type processing).
Get Specialist Advice On Avestin Homogenisers
Contact BPS Crowthorne for technical advice from product specialists on Avestin systems ranging from 1-5 litres/hour (<1 mL holdback) to 1,000 litres/hour (<15 mL holdback).
We can help you to specify the best high pressure homogeniser for your requirements. Key questions include:
- Sample type(s) and viscosity/density
- How many samples do you need to process per day/week?
- Expected total throughput per batch
- Temperature control
- GMP compliance
- Timeline – when do you need your homogeniser to be on-site and operational?
Watch the video (3m 08s) for more information on high pressure homogenisers.
Genevac Centrifugal Solvent Evaporators
Industry-leading solvent evaporators from SP Genevac offer a series of technical benefits for optimum evaporation and sample integrity. They include:
- Dri-Pure® - a unique anti-bumping system that prevents foaming cross-contamination and sample loss due to bumping. It is fitted as standard on the EZ-2, Rocket Synergy and Series 3 HT evaporators.
Read this Glaxo evaluation for more information: “The new generation of Genevac evaporators, incorporating this Dri-Pure® technology, will undoubtedly lead to significant improvements in the quality of samples generated within our labs.” - SpeedTrap™ – as seen on the EZ-2 and miVac evaporators – is a trade-marked, frost-free cold trap that suits a wide range of solvents: volatile organic solvents, water, high boiling point solvents. No defrosting is needed. The quarter-turn collection jar is quick and easy to empty.
- SampleGuard™ –for HT systems – protects samples from overheating when evaporation is complete, removing the need for time-consuming method development. Real-time feedback allows more accurate control of sample temperatures.
The system comprises four thermocouples and a unique sample temperature wireless transmitter. Either one or two probes accurately determine end-of-run for precision performance and automatic shutdown. The probes can measure any point in the sample holder, including the sample. - SampleShield™ temperature control (EZ-2) uses an infrared pyrometer to monitor and control the maximum temperature of the sample holders – removing the need for temperature probes, making loading easier.
SampleShield™ ensures the fastest evaporation rate while protecting samples from overheating (allowing accurate determination of end-of-run).
Genevac’s robust solvent evaporators resist most common solvents and acids used in laboratories, including trifluoroacetic acid (TFA), dichloromethane (DCM, methylene chloride) and dimethyl sulfoxide (DMSO). View the range…
HT Series 3 evaporators – for production laboratories requiring high performance and high sample capacities
- Ultimate solvent removal technology – patented temperature control and bumping prevention
- Latest touchscreen technology – intuitive controls for superior monitoring
- Pre-set ‘press and go’ for popular solvent removal protocols, simple manual and automatic programming
- Smart, rugged, ergonomic design – front opening for easy access
- Optimise your solvent evaporation processes quickly and easily.
EZ-2 Series
The latest Genevac EZ-2 4.0 series centrifugal evaporator for parallel sample evaporation has been redesigned with simplicity in mind and is based on decades of expertise in evaporation science. A modern and compact space-saving design – so you’ll still be able to find space in the fume hood or on the lab bench – the EZ-2 is now even more powerful and versatile to streamline your evaporation workflows and accelerate breakthroughs in life science research.
Key Improvements and Benefits:
- Ergonomic redesign with the SpeedTrap™ jar at the front for easy visibility; removal or replacement is simpler and more intuitive
- Touchscreen interface featuring more pre-set methods for frequently used protocols, methods guide, and recording of all run data
- EXALT™ technology enabling crystallization studies such as polymorph screening
- High power lamps and software improvements enhance overall performance
- Minimized environmental impact with Low Global Warming Potential (GWP) refrigerant, standby mode to help save energy, complete solvent recovery and reduced use of plastic throughout plus recyclable packaging
- Advanced temperature control technology offers total sample protection
- Dri-Pure® anti-bumping technology eliminates bumping and sample loss
- Can accommodate wide choice of sample types
- All-in-one compact design saves valuable bench space in the lab
- Easy maintenance contributes to low cost of ownership
Rocket Series – patented evaporation technology
The Rocket Synergy 2 high speed evaporator is designed to dry or concentrate up to six flasks, each containing a maximum of 450ml of solvent, or 18 ASE® vials, with no user intervention or attention. The removable flask rotor may also be replaced with a 5 litre stainless steel vessel for batch processing. It is five times faster than other ‘intelligent’ evaporators and is capable of replacing several rotary evaporators, saving valuable bench space.
Main benefits:
- No waiting – five times faster than other ‘intelligent’ evaporators
- Perfect results – no monitoring or intervention required for excellent sample recovery
- Error-free – eliminates foaming, bumping and cross-contamination
- Easy to use – simple controls and intelligent software
miVAC Sample Concentrators – high performance, easy to use, space-saving design
- Versatile modular range – for small volume DNA work to high-throughput solvent removal
- Precise temperature controls, fast evaporation
- Only concentrators in their class with solid aluminium rotors – enabling faster speeds for stubborn solvents (such as water)
- Choose from miVac Duo Concentrator (for low sample numbers) or miVac Quattro Concentrator (for more samples)
- Combine your chosen concentrator with a Duo, Quattro or Scroll vacuum pump (depending on the solvents)
- Add options – e.g. SpeedTrap™ cold trap and vacuum controller
- Operate miVAC as a standalone low-volume freeze dryer or a combined concentration/ freeze drying workstation
- Easy to use, compact units with heat and run timers
- Wide range of compatible labware.
The miVAC DNA is a small vacuum concentrator for molecular biology with electro-magnetic drive in the concentration chamber (quiet, maintenance-free). It is faster than other systems in its class, user-friendly and has a clear acrylic lid for monitoring.
Watch this video (2m 14s) for more information about SP Genevac solvent evaporators.
